Nova linha de suplementos oftalmológicos, resultado de 20 anos de pesquisas conjuntas da empresa europeia de biotecnologia Brudylab e do Departamento de Bioquímica e Biologia Molecular da Universidade de Barcelona. A partir desta intensa colaboração, foi obtida em 2009 a patente mundial para o uso do triglicerídeo DHA de alta concentração na proteção antioxidante celular.
Agora no Brasil, este DHA de alta concentração da Brudylab foi licenciado no país pela Yosen, detentora do AVIST® e especialista no desenvolvimento de produtos inovadores no Brasil.
Desde 2024, a Yosen possui suplementos alimentares e nutricionais voltados à saúde ocular, com fórmulas patenteadas e baseadas em estudos científicos e pesquisas clínicas realizadas pela ARVO.
Com foco na pesquisa e síntese de ácidos graxos ômega-3, especificamente na atividade biológica do ácido docosahexaenoico (DHA) nos seres humanos, ela mantém uma relação próxima com a comunidade médica europeia, divulgando os resultados de estudos clínicos que publica nas várias áreas de oftalmologia, como:
1. Reglamento CE Nº 1881/2006 (19 diciembre 2006) que fija el contenido máximo de contaminantes en alimentos y modificación Nº 1259/2011.
2. Linda M Arterburn, et al; Distribution, interconversion, and dose response of -3 fatty acids in humans; Am J Clin Nutr 2006;83(suppl):1467S-76S.
3. Bogdanov P, et al; Docosahexaenoic acid improves endogen antioxidant defence in ARPE-19 cells; ARVO Congress 2008, Poster5932/A306, Thursday, May 01, 2008.
4. Carlos J Contreras; Modificación del daño oxidativo en un grupo de ciclistas tras consumir ácido docosahexaenoico a distintas dosis; Tesis Doctoral, Universidad Católica de Murcia, 2014.
5. Pere Domingo, et al; Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART: A randomized, double-blind, placebo-controlled study; Clinical Nutrition 2017; Jun 8. pii: S0261-5614(17) 30214-5. doi: 10.1016/j. clnu.2017.05.032. [Epub ahead of print].
6. Juan Carlos Martinez-Soto; Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation; Syst Biol
Reproductive Med 2016, 62 (6): 387–395; http://dx.doi.org/10.1080/19396368.2016.1246623
7. Pilar Mancera, et al; Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice; Nutrients
2017, 9, 681; doi:10.3390/nu9070681.
8. M Dolores Pinazo-Durán; Effects of a nutraceutical formulation based on the combination of antioxidants and -3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders; Clinical Int Aging 2013; 8:139-148.
9. C. Galbis-Estrada; Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplement with antioxidants and essential fatty acids; Clin Int Aging 2013;8:711-9.
10. Ribelles Alfredo, et al; Ocular Surface and Tear Film Changes in Older Women Working with Computers; BioMed Research International 2015; Article ID 467039.
11. Maria Lafuente, et al; Combined intravitreal ranibizumab and oral supplementation with docosahexaenoic acid (DHA) and antioxidants for Diabetic Macular Edema: 2-year randomized single-blind controlled trial results; published in RETINA 2017,37:1286-2017.
12. Carmen Galbis Estrada, et al; A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids; Molecular Vision 2015; 21:555-567.
13. Andrea Oleñik, et al; A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction; Clinical Int Aging 2013; 8:1133-1138.
14. Andrea Oleñik, et al; Benefits of Omega-3 fatty acid dietary supplementation on health-related quality of life in patients with Meibomian Gland Disfunction ;Clinical Ophthalmol 2014; 8:831-836.
15. Andrea Oleñik, et al; Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment
of dry eye symptoms: results of a prospective study; Clinical Ophthalmology 2014;8:831-6.
16. Jordi Gatell-Tortajada, et al; Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study; Clin Int Aging 2016; 11:571-578.
17. Jesús Tellez-Vazquez, et al; Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study; Clin Ophthalmol 2016; 10:617-626.
18. Guzman JF, et al; DHA- rich fish oil improves complex reaction time in female elite soccer players; Journal of Sports Sci Med 2011;10:301-5.
19. Popova A Yu, et al, Experience in the use of docosahexaenoic acid (BrudyPlus) in patients with increased spenn DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Ginecology and Perinatology; Andrology & Genital Surgery 2015; 16(2): 51-55.
20. Elena Rodriguez, et al; Supplementation with Docosahexaenoic Acid in Nonproliferative Diabetic Retinopathy: Prospective Controlled Study of Macular Function by Fundus Microperimetry; Comunicación en el 21 Congreso de la SERV, Madrid 3 marzo, 2017. Published in Clinical Ophthalmology 2018; 12:1011-1020.
21. Stéphanie Romeo Villadóniga, Elena Rodríguez García, Olatz Sagastagoia Epelde, M. Dolores Álvarez Díaz, Joan Carles Domingo Pedrol; Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-label Randomized Trial; comunicación en Congreso de la Sociedad Europea de Glaucoma, Florencia, Marzo 2018; Journal of Ophthalmology; Vol 2018, Article ID 8259371, 8 pages; https://doi.org/10.1155/2018/8259371
22. María Lafuente, et al; Three-year outcomes in a randomized single-blind controlled trial of intravitreal ranibizumab and oral supplementation with docosahexaenoic acid and
antioxidants for diabetic macular edema; Comunicación en el 21 Congreso de la SERV, Madrid 4 marzo, 2017. published in RETINA 2019 Jun;39(6):1083-1090. doi: 10.1097/
IAE.0000000000002114.
23. Rodriguez C, et al; Supplementation with High Content Docosahexaenoic Acid Triglyceride in Attention Deficit Hyperactivity Disorder: A Randomized Double-Blind Placebo-
Controlled Trial; Neuropsychiatric Disease and Treatment 2019; 15: 1193-1209.
24. Juan Carlos Martinez-Soto, et al; Effect of dietary DHA supplementation on sperm DNA integrity; Fertility & Sterility 2010; 94(4):S235-S236.
25. Zanón-Moreno V, Raga-Cervera J, Sanz-Gonzalez S, PINAZO-DURÁN MD; Efficacy and safety study of an eyelid gel, after repeated nocturnal application in healthy volunteers; Sent for publication to J Optometry 2019.
26. Vicente Zanón-Moreno, Silvia M. Sanz González, Joan C. Domingo Pedrol, Jorge Raga-Cervera, Juan José Salazar Corral, Maria D. Pinazo-Durán; Feasibility study of an optimized nutraceutic formulation on the blood red cell membrane and macular levels of lutein and docosahexaenoic acid in a healthy mediterranean population; Sent for publication to Food&Function 2019.
27. Results shown in the European Patent EP 1 962 825 B1 (held by BRUDY TECHNOLOGY SL) related to the use of DHA for treating a pathology associated with cellular oxidative damage. European Patent granted, date April 2, 2014.
28. Regulamento da CE em: www.eur-lex.europa.eu; Pesquise a partir do ano e número do Regulamento citado na coluna à direita da tabela indicada na página 9.
Consultar “Estudos e informes” em www.dhavist.com.br
Yosen
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